Revisiting Blob Theory for DNA Diffusivity in Slitlike Confinement Citation

نویسندگان

  • Dai
  • Liang
  • Douglas R. Tree
  • Johan R. C. van der Maarel
  • Kevin D. Dorfman
  • Patrick S. Doyle
  • Liang Dai
چکیده

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Revisiting blob theory for DNA diffusivity in slitlike confinement.

Blob theory has been widely applied to describe polymer conformations and dynamics in nanoconfinement. In slit confinement, blob theory predicts a scaling exponent of 2/3 for polymer diffusivity as a function of slit height, yet a large body of experimental studies using DNA produce a scaling exponent significantly less than 2/3. In this work, we develop a theory that predicts that this discrep...

متن کامل

Revisiting the Conformation and Dynamics of DNA in Slitlike Confinement

We experimentally investigated the equilibrium conformation and dynamics of single DNA molecules in slitlike nanochannels. We measured the in-plane radius of gyration (R )), diffusivity (D), and longest relaxation time (τ) of λ-DNA (48.5 kbp) as functions of the slit height using fluorescence microscopy. Our results show that the in-plane radius of gyration increases monotonically with decreasi...

متن کامل

Intrachain dynamics of large dsDNA confined to slitlike channels.

Exploration of intrachain hydrodynamics of dsDNA within channels has been limited to indirect analysis of global coil dynamics. In this Letter, we isolate hydrodynamic interactions within single molecules of dsDNA confined to slitlike channels by making use of density covariance measurements. We show that the strength of hydrodynamic interactions in DNA is dependent on the intrachain correlatio...

متن کامل

Evaluation of the Kirkwood approximation for the diffusivity of channel-confined DNA chains in the de Gennes regime.

We use Brownian dynamics with hydrodynamic interactions to calculate both the Kirkwood (short-time) diffusivity and the long-time diffusivity of DNA chains from free solution down to channel confinement in the de Gennes regime. The Kirkwood diffusivity in confinement is always higher than the diffusivity obtained from the mean-squared displacement of the center-of-mass, as is the case in free s...

متن کامل

A systematic study of DNA conformation in slitlike confinement†

DNA conformation in slitlike confinement is studied using Monte Carlo simulation and scaling theory. We focus on analysing the in-plane DNA extension as a function of slit height and DNA properties, such as contour length, persistence length and width. Similar to tube confinement, we identify an extended de Gennes regime which is prevalent in many experimental studies. However, unlike previous ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013